With higher standards of living, one might expect more developed and wealthier nations to also be healthier. But in the United States and elsewhere, chronic illness is on the rise. Cancer and heart disease have increased, and so too have autoimmune diseases where the immune system attacks the body's own organs, tissues and cells.

With more than 80 different autoimmune diseases, type 1 diabetes -- also known as juvenile diabetes or insulin-dependent diabetes mellitus (IDDM) -- is one of the most common. The [World Mercury Project](https://worldmercuryproject.org/news/type-1-diabetes-on-the-rise-in-young-children-is-anyone-paying-attention/) has written about a correlation between vaccines and the development of type 1 diabetes in children, as the US has the highest rates of both.

<center><img src="https://i.imgur.com/WBOOg7a.jpg" /><br/><em><sub><a href="https://pixabay.com/en/diabetes-icon-glucose-blood-meter-1710296/">Source</a>, <a href="https://www.flickr.com/photos/niaid/14329622976">Source</a> (<a href="https://creativecommons.org/licenses/by/2.0/legalcode">CC BY 2.0</a>)</sub></em></center>

The incidence rate of type 1 diabetes has been rapidly increasing, especially in [children](https://pdfs.semanticscholar.org/b75a/54670b9fc53bc5bb68e5c3bb0891dc069b1c.pdf). The United States has more children with type 1 diabetes than any other country. Between 2001 and 2009, the prevalence and children and teenagers grew by 21%.

It's pretty bad considering that the US also has the highest number of new cases each year, with more than India which has four times the population. New cases of type 1 diabetes increased by between 2% to 4% each year from 2001 to 2015 for those 19 years old or younger. But for adults with rates fell. A [study](https://www.ncbi.nlm.nih.gov/pubmed/22578579) done in Colorado between the 1990s to 2010 concluded new cases of type 1 diabetes increased at 5.7% per year, with high rates especially found between children 5 to 9 years old.

Diabetes is detrimental to longevity as it cuts lifespan by 10 years when diagnosed at a young age compared to being diagnosed later in life. Early-onset diabetes diagnosed before the age of 10 mean someone has 30 times a greater risk of developing serious cardiovascular outcomes compared to those in the general population. Those who develop diabetes in their 20s see that risk job down to 6 times greater as opposed to 30 times greater.

# Epigenetic Cause?

Something is going on, and it's not simply genetic. Studies are being done to investigate environmental epigenetic influences, such as[ viral infections that trigger](https://www.ncbi.nlm.nih.gov/pubmed/25962204) the onset of type 1 diabetes. Since [1997](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2127500/), the rise of type 1 diabetes in children under five years old in England was being looked at as possibly coming from some environmental factor before birth or in early life after being born.

As one study from [2012](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385937/) put it, the rise of incidence can't be just genetic:

> The substantial increase in the incidence of [type 1 diabetes] among children over recent decades cannot be the consequence only of enhanced genetic disease susceptibility in the population, but largely must be caused by changes in lifestyle and environment.

The most talked about factors are [dietary](https://www.ncbi.nlm.nih.gov/pubmed/28504710) and [viral](https://www.ncbi.nlm.nih.gov/pubmed/27411438). Could it be that vaccines which have live viruses in them are a -- if not the most -- contributing factor to explain the increase in type diabetes among children?

Despite some conclusions that there is no clear evidence the vaccines can induce diabetes and humans, one researcher named JB Classen disagrees, citing animal toxicology studies that show a link between vaccination and increased risk of type 1 diabetes for for specific vaccines: hepatitis B, tuberculosis, measles-mumps-rubella and Haemophilus influenzae type B.

> a spike in the incidence of type 1 diabetes mellitus ... in Finland in 1983 following the introduction of the MMR in both the 0 to 4 and 5 to 9 age groups who received the vaccine starting in late 1982, but not in the 10 to 14 age group who did not receive the vaccine.

Classen has identified a statistical significance of type 1 diabetes occurring 2-4 years after receipt of vaccines. In looking at the benefit or risk of certain vaccines, he found that the [risk](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1114674/#B2) of the illness being vaccinated for might not be as high as developing diabetes from the vaccine:

<blockquote>
Research into immunisation has been based on the theory that the benefits of immunisation far outweigh the risks from delayed adverse events and so long-term safety studies do not need to be performed.

When looking at diabetes—only one potential chronic adverse event—we found that the rise in the prevalence of diabetes may more than offset the expected decline in long-term complications of H influenzae meningitis.

Thus diabetes induced by vaccine should not be considered a rare potential adverse event.
</blockquote>

Classen outlined some [mechanisms](https://www.ncbi.nlm.nih.gov/pubmed/11735306) that can explain how vaccines trigger the onset of type 1 diabetes:

<blockquote>
- molecular mimicry (a phenomenon triggered by the foreign antigens in vaccines, which induce antibodies that cross-react to self-antigens)
- overstimulation of the immune system (prompting the release of proteins known to cause type 1 diabetes)
- skewing of the balance between cell-mediated Th1 immunity (the body’s first line of defense) and humoral-mediated Th2 immunity (responsible for the stimulation of antibodies)
- stimulation of macrophages (innate immune cells that are key players in both type 1 and type 2 diabetes)
- activation of “smoldering” (subclinical) autoimmunity through the action of powerful aluminum and other adjuvants
- replication and release of viruses(such as rubella) known to cause type 1 diabetes
</blockquote>

Although not proven, these questions and observations are important directions that merit further long term study to prove or disprove this theory. It might be hard to get people on board, since there is a lot of [suppression](https://worldmercuryproject.org/news/the-varicella-vaccine-skyrocketing-shingles-and-cdc-chicanery/) when it comes to questioning the holy grail of vaccine efficiency and benefit. This is despite vaccine injury being recognize by the department of Justice in their reports of vaccine injury lawsuit payouts each year. As the World Mercury Project has written about, there are also *"methodological flaws that characterize vaccine [clinical trials](https://worldmercuryproject.org/news/new-study-vaccine-manufacturers-fda-regulators-used-statistical-gimmicks-hide-risks-hpv-vaccines/), [postlicensure monitoring](https://worldmercuryproject.org/what-we-do/hiding-vaccine-related-deaths-semantic-sleight-hand/) and [meta-analyses](https://worldmercuryproject.org/news/garbage-in-garbage-out-researchers-dress-down-cochrane-for-its-flawed-and-biased-review-of-hpv-vaccines/)"*.

A [study](https://www.ncbi.nlm.nih.gov/pubmed/23576057) in 2013 has helped to show how adjuvant-containing vaccines can induce *"adverse events with an autoimmune or inflammatory component"*, finding that *"76% of the events occurred in the first 3 days post-vaccination"*. A [review report](https://www.ncbi.nlm.nih.gov/pubmed/27435706) published in 2017 discussed how a 14 year old was diagnosed with type 1 diabetes a few weeks after receiving a diphtheria-tetanus-acellular pertussis (DTaP) booster vaccine, with Systemic Lupus Erythematossus following several years later.

Since Classen's publication in 2001, little has changed regarding how vaccines are administered. It seems that the vaccination rates and type 1 diabetes rates have kept increasing. Is this just a correlation, or is there a real causation at play for one to lead to the development of the others? Classen's introductory remarks should make more people stop to think about the issue:

<blockquote>
Vaccine studies have labelled a vaccine safe if it causes few adverse events in a usually small study group followed for no more than 30 days post-immunization.

Data linking vaccines to a rise in a wide variety of immunological diseases such as type I insulin-dependent diabetes mellitus ... has outlined the pressing need for rigorous long-term vaccine safety studies.

It is becoming increasingly clear that the effect of vaccines on the immune system is much more complicated than originally believed, underlining the inadequacy of current safety studies, because vaccines differ from the infections they prevent and have different effects on the immune system.
</blockquote>

Just because some children aren't developing type 1 diabetes or other autoimmune issues a short time after receiving a vaccine doesn't mean that it's not happening in other children. If there is a safety issue with developing type 1 diabetes from certain vaccines, everyone should know about that reality. There is far too much denial that vaccine are not 100% safe for 100% of everyone 100% of the time. If it's admitted, then the usual line is that "the benefits outweigh the risks". But what if it was your child who was injured by a vaccine? I think your tune would change, as it has for many parents whom that has happened to.

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