Curie and OCD are two of the largest curation projects on steem. They offer big upvotes to new users creating quality content. In Curie's case, these votes can be worth $80+. 

For Curie, you are not eligible for upvotes unless your post is worth less than $1 and your reputation is 52 or lower. This is because the goal is to support new, unestablished users - to get them some rewards and recognition for the hard work they do.

Whenever a new user boosts their posts via upvote bots, they usually end up earning 3-5 bucks... minus whatever they pay for the bots. This makes them ineligible for Curie and only earns then a dollar or two of profit. It's a real shame, IMO.