It's maybe time for such person to be knocked out of her/his "un-comfort" zone by medicating them psychedelics.

as state in this article, depressed persosn cannot make move out of their inner self defeating world. 

I advocate for transpersonal therapy like rebirth or holotropic breathing.

Psychedelics opens doors of perception and possibly give new insight on the burdens that a person carries.
Such a trip should be done under supervision of experience & trained person. LiKe the Zendo project..

Thank for sharing your story !