Viewing a response to: @aboutcoolscience/much-more-than-macrophages
I think it's pretty interesting. There were previous reports from Michael Karin and David Brenner lab that found FSP1, F4/80 double positive cells in a model of liver injury. However, they reported that these cells do not show do not show the expression of alpha-SMA. Moreover in their study these cells were different from col1a producing cells. What is really interesting about this study is that these cells are actually turning on col1a expression. Which would definitely be a classic fibroblast like cell. It would however be inresting to see if PDGFRa driven CRE in wound condition can also show F4/80 expression. Or maybe I missed that while skimming through the paper.
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