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Physics is a type of natural science. Conversely, metaphysics is a branch of philosophy. It studies the fundamental nature of being and the world. Physics involves the study of matter and its motion and behavior through space and time, along with related concepts such as energy and force. One of the most fundamental scientific disciplines, the main goal of physics is to understand how the universe behaves.
Topics of metaphysical investigation include existence, objects and their properties, space and time, cause and effect, and possibility. A central branch of metaphysics is ontology, the investigation into the basic categories of being and how they relate to one another. However, space and time are common as topics.

Physics in Science

Physics makes significant contributions through advances in new technologies that arise from theoretical breakthroughs. For example, advances in the understanding of electromagnetism or nuclear physics led directly to the development of new products that have dramatically transformed modern-day society, such as television, computers, domestic appliances, and nuclear weapons; advances in thermodynamics led to the development of industrialization, and advances in mechanics inspired the development of calculus.

Metaphysics in Science

An example from biology of Lakatos' thesis: David Hull has argued that changes in the ontological status of the species concept have been central in the development of biological thought from Aristotle through Cuvier, Lamarck, and Darwin. Darwin's ignorance of metaphysics made it more difficult for him to respond to his critics because he could not readily grasp the ways in which their underlying metaphysical views differed from his own. 
In physics, new metaphysical ideas have arisen in connection with quantum mechanics, where subatomic particles arguably do not have the same sort of individuality as the particulars with which philosophy has traditionally been concerned. Also, adherence to a deterministic metaphysics in the face of the challenge posed by the quantum-mechanical uncertainty principle led physicists such as Albert Einstein to propose alternative theories that retained determinism. 
In chemistry, Gilbert Newton Lewis addressed the nature of motion, arguing that an electron should not be said to move when it has none of the properties of motion. 
Katherine Hawley notes that the metaphysics even of a widely accepted scientific theory may be challenged if it can be argued that the metaphysical presuppositions of the theory make no contribution to its predictive success.