<center>![Research 1.png](https://steemitimages.com/DQmQjutHW7NwryuYZMaT4xjLXinvyd1FLHcZwSbcio3dKqT/Research%201.png)</center> ___ Chen and Chan recently (June 22, 2017) published a [research review](http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30340-6) in _Cell Metabolism_, in which they look at the similarities of cancer cells and stem cells with respect to their metabolic profile. Specifically, they go in-depth with regards to the mitochondrial dynamics: the roles of mitochondrial fission and fusion and the progression of cell proliferation. Cells, depending on their type, can have thousands of mitochondria, making their dynamics a good research focus. Broadly speaking, mitochondrial fission seems to be associated: - in some cancer cells: with higher proliferation and invasiveness, and increase glycolytic metabolism - in some stem cells: with higher self-renewal and resistance to differentiation Mitochondrial fission and fusion are very complex processes driven by and regulated by a multitude of proteins and other factors, notably _DRP1_ and _DYN2_ in fission. For the technical reader, the authors go into the mechanisms and interactions of and between these factors. The Warburg effect and the role of reactive oxygen species in tumor progression are also discussed: _"Differentiated cells typically rely heavily on the OXPHOS activity of mitochondria. In contrast, many cancer cells show the arburg effect, characterized by reliance on aerobic glycolysis and reduced emphasis on OXPHOS. Glycolysis, though less energy efficient than OXPHOS, generates metabolic intermediates that provide building blocks for synthesis of amino acids (AAs), fatty acids (FAs), and nucleotides (NTPs)."_ [[source](http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30340-6)] Mitochondria fusion seems to be the opposite of fission for cell growth, thereby having an inhibitory effect - in breast and lung cancer cells. Mitochondrial dynamics are then explored in the context of stem cells and (already) differentiated cells. The perspectives raised by the authors with respect to the research venues that should be further pursued involve: - further investigation on the resemblance between the metabolisms of cancer cells and of stem cells - whether or not mitochondrial fission arises from a change in metabolism or other cell processes - further investigation of the relationship between mitochondrial morphology and metabolism - how a better understanding of these issue could drive the development of therapies against tumorigenesis and progression. Overall, this is an [interesting paper](http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30340-6) that I recommend to those with a strong interest in cancer research. ___ ### <center>To stay in touch with me, follow @cristi </center> ___ [Cristi Vlad](http://cristivlad.com), Self-Experimenter and Author
post_id | 4,918,777 |
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author | cristi |
permlink | mitochondrial-dynamics-in-relation-to-cancer-and-stem-cell-phenotypes-june-2017-research |
category | science |
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So, just to check if I understood, stem cells may inhibit the growth of cancer cells? I don't know to much about this topic so...
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no, this looks into the similar mitochondrial dynamics of cancer cells and stem cells - broadly speaking...
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I can't recall the last time i heard the word metachondrial i hope i spelled that correctly lol. It sounds very scientific. Next time i say something stupid i will always be like *I have this word stuck in my head~ Metachondrial* so they think I'm super science nerd or something hahaha
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it's mitochondrial...lol :)
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Interesting information. For me is too scientific. Thanks for sharing!
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This post received a 3.1% upvote from @randowhale thanks to @cristi! For more information, [click here](https://steemit.com/steemit/@randowhale/introducing-randowhale-will-you-get-the-100-vote-give-it-a-shot)!
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Bloody hell this is advanced science isn't it. Great post
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thanks!
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Great blog! Check out my new post @the.dajboz follow me! :)
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This is a nice research paper summary. We need more of this sort of thing on Steemit. Keep it up!
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very good post. upvoted & following u. looking forward to your next post. hope uwill like my this post. pls upvote it. https://steemit.com/science/@ika497/do-you-want-to-test-your-intelligence-6-pictures-to-test-your-intelligenece-have-fun thanks.
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Oh shit, when I see mitochondrial in my feed I know it's cristi, will read later when I want to hurt my head
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lol...what I posted are just a few small thoughts...if you read the paper, then you'll get a headache :)
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