Cannabigerol treats antibiotic-resistant bacteria (MRSA) by medikatie

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cannabis · @medikatie ·
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Cannabigerol treats antibiotic-resistant bacteria (MRSA)
Infectious Disease Researchers at McMaster University in Ontario, Canada and immunologists at the University of Alexandria in Egypt have collaborated on <a href="https://pubmed.ncbi.nlm.nih.gov/32017534">a new study</a> unlocking the antibiotic potential of <a href="https://en.wikipedia.org/wiki/Cannabigerol">cannabigerol (CBG)</a>, a potent therapeutic cannabinoid. 

<center>![id9b00419_0007.gif](https://cdn.steemitimages.com/DQmZckXouK18NoQckFJxX6ppKoovciF8nwScEFqsCR2cPH4/id9b00419_0007.gif)</center>

The researchers found that cannabinoids have antibacterial activity against <b>methicillin-resistant Staphylococcus aureus</b> <a href="https://www.mayoclinic.org/diseases-conditions/mrsa/symptoms-causes/syc-20375336">(MRSA</a>) in mice similar to standard antibiotics. They report cannabinoids inhibit the ability of MRSA to form <a href="https://en.wikipedia.org/wiki/Biofilm">biofilms</a>.

<center>![CBG.png](https://cdn.steemitimages.com/DQma816N7tBNWcJAkYBKDSHLBkzBruUmx3ZnHjw7AS36D3v/CBG.png)</center>


Many cannabinoids are effective against <a href="https://en.wikipedia.org/wiki/Gram-negative_bacteria">Gram-negative organisms</a>, which have a outer permeabilized membrane. <b>Cannabigerol</b> also targets the inner cytoplasmic membrane of <a href="https://en.wikipedia.org/wiki/Staphylococcus_aureus">Gram-positive organisms</a>.


<center>![Load.png](https://cdn.steemitimages.com/DQmYAmDHja273X6FyT6yWFhrfommxM8bnHrMG6uLZ512u18/Load.png)</center>

<blockquote> "Cannabinoids work in combination with <a href="https://en.wikipedia.org/wiki/Polymyxin_B">polymyxin B</a> against multidrug resistant Gram-negative pathogens, revealing the broad-spectrum therapeutic potential for cannabinoids." </blockquote>

<center><b>Source:</b></center>

Farha, M. A., El-Halfawy, O. M., Gale, R. T., MacNair, C. R., Carfrae, L. A., Zhang, X., Jentsch, N. G., Magolan, J., & Brown, E. D. (2020). <a href="https://pubmed.ncbi.nlm.nih.gov/32017534"><b>"Uncovering the Hidden Antibiotic Potential of Cannabis"</b>.</a> <i><b>ACS infectious diseases</b></i>, DOI: 10.1021/acsinfecdis.9b00419. Advance online publication. <a href="https://pubs.acs.org/doi/10.1021/acsinfecdis.9b00419">Click here</a> to view graphs and tables.
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@girlsofgreen ·
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According to a recent <a href="https://www.forbes.com/sites/janellelassalle/2019/09/11/why-cbg-cannabigerol-expensive-produce/#20e9a0f42f77">Forbes article</a>, cannabigerol is an expensive cannabinoid because of its rarity and difficult extraction process, but that <a href="https://pubmed.ncbi.nlm.nih.gov/31943398">process</a> is well-documented in the literature and seems pretty easy. How hard and expensive is it really to analyze and isolate cannabinoids? Isolating cannabinoids and making combinations of them (without patents) is what the real cannabis "industry" should be. It would be the holy grail of medicine....East meets West :)
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@drutter ·
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While these findings aren't directly applicable to the current viral outbreak from China, they hint that many more breakthroughs with antimicrobial cannabinoids are waiting to be discovered!
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@greatesteem ·
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@MediKatie, is CBG the most antibacterial cannabinoid currently known?
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@medikatie ·
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Good question. You can see a graph of the antibacterial action of various different cannabinoids investigated in the study <a href="https://pubs.acs.org/doi/10.1021/acsinfecdis.9b00419">here</a>. Other studies show that <a href="https://pubmed.ncbi.nlm.nih.gov/18681481">all the major cannabinoids</a> (and perhaps their entourage effect) are antibacterial, but my gut tells me that there's something special about <a href="https://pubmed.ncbi.nlm.nih.gov/7298870">cannabichromene</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/7153877">cannabigerol</a>.
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@girlsofgreen ·
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Cannabichromene is also <a href="https://pubmed.ncbi.nlm.nih.gov/7298870"> antifungal</a>. They're anti-sickness basically and there's hundreds of them, and terpenes too, all working synergystically to balance us and bring good health.
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@drutter · 
Cannabinoid <i>entourage</i> antimicrobial action? Okay, that's getting pretty interesting.
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