Psilocybin mushroom are in the same family compound (tryptamines) as LSD and DMT the active compound of ayahusca. They act on the same neuro-transmitter and have been reported to induce similar experience. 

The family includes neurotransmitter serotonin (5-hydroxy tryptamine) and hallucinogenic/psychedelic drugs such as LSD, Psilocybin (magic mushrooms) - both widely-used, and other, less common, synthetic drugs such as dimethyl-tryptamine (DMT). 

> Other than the duration of the experience, the effects of psilocybin are similar to comparable dosages of LSD or mescaline. However, in the Psychedelics Encyclopedia, author Peter Stafford noted, "The psilocybin experience seems to be warmer, not as forceful and less isolating. It tends to build connections between people, who are generally much more in communication than when they use LSD."[22]


https://upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Biosynthesis_of_psilocybin.svg/800px-Biosynthesis_of_psilocybin.svg.png

Diagram detailing the biosynthesis of psilocybin from tryptophan

There are plenty of studies that suggest the positive benefits of LSD as well.  

https://www.theguardian.com/science/2015/mar/05/psychedelic-drugs-like-lsd-could-be-used-to-treat-depression-study-suggests

Psychedelic drugs could prove to be highly effective treatments for depression and alcoholism, according to scientists who have obtained the first brain scans of people under the influence of LSD.

https://www.washingtonpost.com/posteverything/wp/2016/04/01/lsd-could-make-you-smarter-happier-and-healthier-should-we-all-try-it/?utm_term=.29cf2ef0e7e3

But over the past decade, some scientists have begun to challenge that conclusion. Far from being harmful, they found, hallucinogens can help sick people: They helped alcoholics drink less; terminal patients eased more gently into death. And it’s not just the infirm who are helped by the drugs. Psychedelics can make the healthy healthier, too.

https://www.livescience.com/43894-acid-lsd-therapeutic-value-benefits.html

The LSD experiment is part of a growing trend toward taking certain drugs — long dismissed as "recreational" — more seriously for their therapeutic value. Despite a plethora of federal and state prohibitions against drug-related testing and research, investigators are discovering that many so-called party drugs have real health benefits.

LSD isn't addictive, and unless taken by someone with an existing predisposition towards mental illness, unlikely to do any sort of lasting harm.  The demonization of LSD & other psychedelics is pretty laughable when you consider the harm done by legal drugs such as alcohol, pain killers, nicotine, etc.