Let's not just forget about all the positive outcome some drugs can induce. 

>Rigorous study hailed as landmark

> Using unusually rigorous scientific conditions and measures, Johns Hopkins researchers have shown that the active agent in “sacred mushrooms” can induce mystical/spiritual experiences descriptively identical to spontaneous ones people have reported for centuries.

> The resulting experiences apparently prompt positive changes in behavior and attitude that last several months, at least.

...

> One third said the experience was the single most spiritually significant of their lifetimes; and more than two-thirds rated it among their five most meaningful and spiritually significant. Griffiths says subjects liken it to the importance of the birth of their first child or the death of a parent.

> Two months later, 79 percent of subjects reported moderately or greatly increased well-being or life satisfaction compared with those given a placebo at the same test session. A majority said their mood, attitudes and behaviors had changed for the better.  Structured interviews with family members, friends and co-workers generally confirmed the subjects’ remarks. Results of a year-long followup are being readied for publication.

http://www.hopkinsmedicine.org/press_releases/2006/07_11_06.html

> 'Magic Mushrooms' May Permanently Alter Personality 

> Just one strong dose of hallucinogenic mushrooms can alter a person's personality for more than a year and perhaps permanently, a new study finds.

> People given psilocybin, the compound in "magic mushrooms" that causes hallucinations and feelings of transcendence, demonstrated a more "open" personality after their experience, an effect that persisted for at least 14 months. Openness is a psychological term referring to an appreciation for new experiences. People who are more open tend to have broad imaginations and value emotion, art and curiosity.

https://www.livescience.com/16287-mushrooms-alter-personality-long-term.html

> Magic Mushrooms Create a Hyperconnected Brain

>The active ingredient in the psychedelic drug, psilocybin, seems to completely disrupt the normal communication networks in the brain, by connecting "brain regions that don't normally talk together," said study co-author Paul Expert, a physicist at King's College London.

https://www.livescience.com/48502-magic-mushrooms-change-brain-networks.html

> Magic Mushrooms Can Erase Fear in Mice

> The active ingredient in hallucinogenic mushrooms may erase frightening memories and encourage new brain cell growth in mice, a new study suggests.

> Mice given an electric shock, then a low-dose of the hallucinogen psilocybin, lost their fearful response to a sound associated with a painful electric shock much more quickly than mice that didn't receive the drug.

https://www.livescience.com/37914-psilocybin-eliminates-traumatic-memories.html

> Psilocybin inhibits the processing of negative emotions in the brain

https://www.sciencedaily.com/releases/2014/05/140507095756.htm